When the young and beautiful Jacquetta is married to the older Duke of Bedford, English regent of France, he introduces her to a mysterious world of learning and alchemy. Her only friend in the great household is the duke's squire Richard Woodville, who is at her side when the duke's death leaves her a wealthy young widow. The two become lovers and marry in secret, returning to England to serve at the court of the young King Henry VI, where Jacquetta becomes a close and loyal friend to his new queen.

The Woodvilles soon achieve a place at the very heart of the Lancaster court, though Jacquetta has visions of the growing threat from the people of England and the danger of their royal York rivals. Jacquetta fights for her king and queen, as she sees an extraordinary and unexpected future for her daughter Elizabeth: a change of fortune, the white rose of York, and the throne of England...