This special issue contains the most up-to-date, complete evaluation of the issues and evidence associated with the landmark revision to the MMPI-2 and the development of Restructured Clinical (RC) Scales. A wide range of topics are discussed, such as the problem of confounding variance from the MMPIs first factor; the relative merits of developing scales via criterion keying versus logical construction, and, correspondingly, the relative merits of complex and heterogeneous scales versus narrow and unidimensional scales; and the ongoing challenges of discriminant validity and incremental validity. Contributors offer their expertise on the RC Scales and provide a better understanding of these new scales in order to draw accurate, informed inferences in applied work with the MMPI-2. Readers will advance their understanding of issues that transcend the MMPI itself. The articles will stimulate thought, discussion, and further research for optimal clinical personality assessment.