Nova Science Publishers now introduce an interesting book on research to help reduce global tobacco-related diseases in four volumes. Volume One describes general topics on nicotinism and the emerging role of electronic cigarettes; Volume Two describes basic molecular biology of nicotinism; Volume Three describes emerging biotechnology in nicotinism; and Volume Four describes chronic diseases associated with nicotinism and disease-specific-spatiotemporal (DSST) charnolosomics and charnolopharmacotherapeutics for the targeted, safe and effective personalized theranostics of nicotinism. The most interesting and unique feature of this book is that it introduces the original concept of disease-specific spatio-temporal (DSST) charnolosomics along with conventional omics (including genomics, proteomics, metabolomics, lipidomics, and metallomics) by employing combinatorial and correlative-bioinformatics to accomplish targeted, safe, and effective perosonalized theranostics of nicotinism. This book presents basic molecular biology and pharmacogenomics of nicotinism and the emerging role of e-cigarettes as an alternative to reduce tobacco cravings and related health risks, and to prevent second hand smoking-related health risks. The book illustrates specifically the novel concept of mitochondrial bioenergetics-based charnolopharmacotherapeutics for the clinical management of nicotinism with future prospects to minimize tobacco smoking behavior, and/or quit smoking with minimum withdrawal symptoms. This book presents recent knowledge and wisdom regarding more harmful aspects and limited therapeutic benefits of tobacco smoking through incineration or by vaping through e-cigarettes. The book is primarily for the health and well-being of highly vulnerable adolescents, who engage in drug seeking behavior, become victims of chronic tobacco addiction, and suffer from poor quality of life, early morbidity, and mortality. Moreover, tobacco exposure during intrauterine life can induce diversified embryopathies (such as abortion, stillbirth, sudden infant death syndrome, microcephaly, craniofacial abnormalities, growth retardation, ADHD, autism, and craniofacial abnormalities) in developing infants; and asthma, COPD, cancer, and infertility in adults. Hence, the primary goal is to minimize tobacco-induced early morbidity and mortality due to asthma, emphysema, cancer, heart attack, diabetes, obesity, infertility, major depressive disorders, schizophrenia, Alzheimer's disease, and several other neurological and neuropsychiatric disorders.. Volume Four describes chronic diseases associated with nicotinism and novel disease-specific-spatiotemporal (DSST) charnolosomics and charnolopharmacotherapeutics for the targeted, safe and effective personalized theranostics of nicotinism. This volume is systematically presented in three sections. Sections One: "Disease-Specific Nicotinism" consists of eight chapters: Chapter One - "Nicotine and Stroke"; Chapter Two - "Nicotine and Diabetes"; Chapter Three - "Nicotine and Obesity"; Chapter Four - "Nicotine and Parkinson's Disease"; Chapter Five - "Nicotine and Alzheimer's Disease"; Chapter Six - "Nicotine and Schizophrenia"; Chapter Seven - "Nicotine and Major Depressive Disorders"; and Chapter Eight - "Nicotine and Cancer". Section Two: "Charnolopharmacotherapeutics of Nicotinism" consists of Chapter Nine, which describes the therapeutic potential of disease-specific spatiotmporal charnolopharmaceuticals in nicotinism, and Section Three highlights conclusions and future directions. Those interested in learning more about the basic molecular biology, molecular genetics, emerging biotechnology, diseases linked to nicotinism, and their possible prevention and cure will find this book interesting, exciting, motivating, and thought-provoking. This book is written primarily for biomedical students, researchers, scientist, professors, doctors, nurses, and any members of the general public interested in enhancing their existing knowledge and wisdom regarding the deleterious effects of both conventional as well as emerging e-cigarettes on human health and well-being, particularly among adolescents and young adults.
