Polyphenolics are compounds found in plants, such as phenolic acid and flavonoids, that have positive effects on human health and help fight disease. As such, studies of these compounds are valuable for those looking to improve their own health or the health of others. Chapter One addresses the role that polyphenolics plays in the assessment of food integrity and authenticity. Chapter Two studies the potential of regular long-term consumption of various fruit species for reducing diabetes mellitus. Chapter Three provides a platform for the selection of solvent for extraction, column and mobile phase for better separation of polyphenol compounds. Chapter Four presents extraction with subcritical water as a technique for polyphenol isolation. Lastly, Chapter Five attempts to bridge the gap between the different ethnomedical and folklore claims of utilization of Amaranth germplasms against degenerative diseases with matching polyphenol-based chemical data having antioxidant and anti-inflammatory properties.