This volume contains the proceedings of the Alexandre Vinogradov Memorial Conference on Diffieties, Cohomological Physics, and Other Animals, held from December 13-17, 2021, at the Independent University of Moscow and Moscow State University, Moscow, Russia. The papers are devoted to various interrelations of nonlinear PDEs with geometry and integrable systems. The topics discussed are: gravitational and electromagnetic fields in General Relativity, nonlocal geometry of PDEs, Legendre foliated cocycles on contact manifolds, presymplectic gauge PDEs and Lagrangian BV formalism, jet geometry and high-order phase transitions, bi-Hamiltonian structures of KdV type, bundles of Weyl structures, Lax representations via twisted extensions of Lie algebras, energy functionals and normal forms of knots, and differential invariants of inviscid flows. The companion volume (Contemporary Mathematics, Volume 789) is devoted to Algebraic and Cohomological Aspects of PDEs.