St Francis of Assisi, one of the most acclaimed and enduring of saints, is particularly significant when reflecting upon the COVID pandemic. Francis lived, and ministered, amid a leprosy pandemic. How he lived in relation to that pandemic makes him a source of insight to as well as a potential critic of contemporary responses to COVID. In turn, one can use COVID to question Francis. Did he exhibit a harmful form of religious devotion, perhaps fanaticism, by exposing himself and others to a lethal pathogen? This edited collection examines a highly visible and impactful religious figure with the intent of bringing him into conversation with one of the defining issues of the early 21st Century.