This volume contains the proceedings of the summer school and research conference "Frontiers in Geometry and Topology", celebrating the sixtieth birthday of Tomasz Mrowka, which was held from August 1-12, 2022, at the Abdus Salam International Centre for Theoretical Physics (ICTP). The summer school featured ten lecturers and the research conference featured twenty-three speakers covering a range of topics. A common thread, reflecting Mrowka's own work, was the rich interplay among the fields of analysis, geometry, and topology. Articles in this volume cover topics including knot theory; the topology of three and four-dimensional manifolds; instanton, monopole, and Heegaard Floer homologies; Khovanov homology; and pseudoholomorphic curve theory.