This book offers an in-depth examination of the historical, political, and socio-cultural dimensions of psychoactive substance use, particularly within the Brazilian context. It provides a detailed analysis of the evolution of policies and approaches towards prohibitionism and criminalization, emphasizing their impact on marginalized and socially stigmatized groups. Through a comparative lens, it explores alternative regulatory models, exemplified by Uruguay's Cannabis legalization trajectory. Additionally, the work critically examines the complex interplay between gender, media representations, and illicit drug trafficking, shedding light on the intricate dynamics involved. Central to its discourse are preventive strategies and harm reduction interventions, which underscore the pivotal role of education, neuroscience, and community-based approaches in addressing substance use among adolescents. Drawing from diverse disciplinary perspectives, including neuroscience, psychology, and public health, the book offers a comprehensive understanding of substance use and dependence. By synthesizing research findings and evidence-based practices, it serves as a valuable resource for policymakers, healthcare professionals, educators, and researchers engaged in addiction studies, mental health, and public policy formulation.
